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CPSC Lecture with Katayoon Dehesh – University of Copenhagen

Copenhagen Plant Science Centre > Event calendar > 2017 > CPSC Lecture with Kata...

CPSC Lecture with Katayoon Dehesh

Choreography of plastidial retrograde signaling network in interorganellar communication

Interorganellar communication is an evolutionary necessity for maintenance of cellular homoeostasis in response to prevailing environment that, in part, is exquisitely controlled via retrograde-signaling pathways. We have identified a novel stress-specific plastidial retrograde signalling metabolite, methylerythritol cyclodiphosphate (MEcPP), previously known solely as an intermediate in the isoprenoid biosynthetic pathway.

The additional function of MEcPP as a stress sensor and a coordinator of transcriptional and post transcriptional regulation of key stress-responsive nuclear genes, has unraveled the central role of this metabolite in cellular functions in response to a wide range of environmental and developmental cues.

To identify the underlying molecular mechanism of the MEcPP-mediated stress responses, we have performed a multi-omics approach. These studies have led to the identification of a transcriptional hub activated by MEcPP, and have further established a previously unrecognized link between this plastidial retrograde signal and the transcriptional reprogramming of endoplasmic reticulum genes critical for readjustment of protein-folding capacity in stressed cells.

Lastly, we have gained an insight into the molecular mechanism by which MEcPP regulates plant growth and development in response to stress. In brief we have advanced our understanding of how MEcPP reprograms a repertoire of intricate networks crucial for coordinating the physiological and metabolic processes required for stress-induced developmental responses and stress adaptation.

These studies offer an insight into functional module concept of biological organization and regulation by MEcPP, the plastidial retrograde signaling metabolite and a coordinator of interorganellar communication.

Time: 25 September 15:00-16:00
Place: Thorvaldsensvej 40, lecture room A2-70.03.

Meeting with Katayoon Dehesh:
If you would like to meet with Prof. Dehesh during her stay, please contact Lene Rasmussen about seeeting up a meeting.