Symposium with Mar Alba & Josh Gendron – University of Copenhagen

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Symposium with Mar Alba & Josh Gendron

 "lncRNAs - peptides - decoys"

On 25 August Joshua Gendron from Yale University and Mar Alba from Universitat Pompeu Fabra & ICREA will give a symposium on “lncRNAs - peptides – decoys”. The symposium will be at Thorvaldsensvej 40 in lecture room A2-70.03 at 9.00-11.00 o’clock.

Joshua Gendron, Yale University, USA

“Circadian Mechanisms of Protein Degradation.”

Organismal fitness is optimized by sensing and responding to environmental cues. One of the strongest cues is the daily cycle of light and dark caused by rotation of the earth. In many organisms daily light patterns are interpreted by a molecular mechanism called the circadian clock. The circadian clock then distributes biological activities throughout the day. Most eukaryotic circadian clocks are composed of interconnected transcriptional and translational feedback loops. Much is known about the generation of daily rhythmic transcription of clock genes. In contrast, little is known about how daily rhythms of protein concentration are achieved. My laboratory uses reverse genetics and mass spectrometry to break apart the protein complexes that control rhythmic protein degradation in plants.

Mar Alba, Universitat Pompeu Fabra and Catalan Institution for Research and Advanced Studies, Barcelona, Spain

"Identification of novel peptides using ribosome profiling."

Massive sequencing of RNA (RNA-Seq) allows the quantification of different RNA molecules in the cell. Ribosome profiling (Ribo-Seq) is a modification of this technique that identifies which parts of the mRNAs are translated into proteins. Using Ribo-Seq we have discovered hundreds of small proteins which are translated from RNAs annotated as long non-coding RNAs (lncRNAs). Many of these peptides are conserved across species and show signatures of purifying selection, indicating that they are functional peptides that have been missed due to their short size. Other lncRNAs appear to be species-specific and are likely to have originated de novo. We conclude that lncRNAs are an important source of new peptides.

The symposium is part of a networking project between Yale University and Copenhagen Plant Science Centre funded. The project is funded by the Danish Agency for Science Technology and Innovation. Read the news story about the grant here.