CPSC Lecture with Sarah E. O'Connor – University of Copenhagen

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CPSC Lecture with Sarah E. O'Connor

Catharanthus roseus.

Professor Sarah E. O’Connor from John Innes Center, Department of Biological Chemistry, Norwich, UK will give a CPSC Lecture on 15 September at 15.00-16.00. Everybody is welcome.

"Understanding and Engineering Indole Alkaloid Biosynthesis"

Many enzymatic transformations are utilized in the biosynthesis of the iridoids, and the alkaloid derived from iridoids, known as the monoterpene indole alkaloids. Here we describe the discovery, functional characterization and mechanistic study of several enzymes involved in the biosynthesis of the iridoids and the monoterpene indole alkaloids in several plant species.

The O’Connor group investigates how plants and plant pathogens produce complicated molecules from simple metabolic building blocks. They are currently focusing on identifying the genes from Catharanthus roseus that make a class of natural products known as the monoterpene indole alkaloids.

The group uses bioinformatics approaches to identify gene candidates from sequence data, which are then subjected to functional characterization using in vitro biochemical assays. They also assess the function of the genes in planta using silencing techniques such as RNAi or VIGS.

These newly identified enzymes are then used in synthetic biology efforts and in mechanistic enzymology studies. The group is extremely excited about being able to harness the completely novel biochemistry encoded within this complex alkaloid pathway network.

Time: 15 September 2016, 15:00-16:00

Place: Thorvaldsensvej 40, 1871 Frederiksberg C, lecture room A2-70.03.

Would you like to meet with Sarah E. O’Connor on 15 September?
Please contact Lene Rasmussen lras@plen.ku.dk if you would like to set up a meeting with Professor O'Connor or if you would like to join the postdoc and PhD meeting for young researchers.