CPSC lecture by John Mundy: "Innate immunity in a moss" – University of Copenhagen

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CPSC lecture by John Mundy: "Innate immunity in a moss"

John Mundy from Plant Molecular Biology, Department of Biology, UCPH will give a CPSC Lecture on 21 January 2016.

AP kinase (MPK) cascades in Arabidopsis and other vascular plants are activated by developmental cues, abiotic stress and pathogen infection. Little is known of MPK functions in nonvascular plants such as the phylogenetically ancient moss P. patens. We provide evidence for a signaling pathway in P. patens required for immunity triggered by pathogen associated molecular patterns (PAMPs).

This pathway induces rapid growth inhibition, a novel fluorescence burst, cell wall depositions, and accumulation of defense-related transcripts. Two P. patens MPKs (Pp MPK4a and Pp MPK4b) are phosphorylated and activated in response to PAMPs. This activation in response to the fungal PAMP chitin requires a chitin receptor, two MAP kinase kinase kinases and at least one MAP kinase kinase.

Knockout lines of Pp MPK4a appear wild type but have increased susceptibility to the pathogenic fungi Botrytis cinerea and Alternaria brassisicola. Both PAMPs and osmotic stress activate some of the same MPKs in Arabidopsis. In contrast, ABA treatment or osmotic stress of P. patens does not activate Pp MPK4a or any other MPK, but activates at least one SnRK2 kinase. Signaling via Pp MPK4a may therefore be specific to immunity, and the moss relies on other pathways to respond to osmotic stress.

Simon Bressendorff, Raquel Azevedo, Chandra Shekar Kenchappa, Inés Ponce de León, Magnus Wohlfahrt Rasmussen, Gitte Erbs, Mari-Anne Newmann, Morten Petersen and John Mundy

About John Mundy
John Mundy is Professor at Section for Functional Genomics at Department of Biology, University of Copenhagen. He has been a professor at UCPH since 1995 including 6 years as Science Faculty Vice-Dean for Research and 5 years as Vice-Head of the Departments of Biology and Molecular Biology.

His current research in the Section for Functional Genomics focuses on Innate immunity (How do plants defend themselves against pathogens?), programmed cell death (How do plant cells die?) and signal transduction.

Section for Functional Genomics.
Plant Molecular Biology group.

Time: 21. january 2016, 15:00-16:00

Place: Thorvaldsensvej 40, 1871 Frederiksberg C, lecture room A2-70-04

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