Spatially confined protein – University of Copenhagen

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Copenhagen Plant Science Centre > Meet the Scientists > Mathias' group > Spatially confined pro...

Spatially confined protein targeting to the thylakoid membrane

The random insertion of components of a multi-enzyme pathway into the thylakoid membrane very often come at the expense of a significant impairment in photosynthetic efficiency and low product yields. To overcome such constraints we aim to implement a modular protein-anchor technology to spatially confine and cluster pathways involving multiple enzymatic steps in defined thylakoid membrane domains.

CURT1-family proteins occur at the curved margins of thylakoid grana stacks. The grana margins are devoid of photosynthetic proteins, and by attaching metabolic enzymes to CURT1-family proteins we can potentially cluster metabolic pathways in the chloroplast without impairing photosynthetic functions.